The Role of Deleterious Mutations


Figure 1 from Kono et al. (2016). The Role of Deleterious Substitutions in Crop Genomes. MBE 33: 1669-1678

Deleterious Mutations and the Response to Strong Selection in a Self-fertilizing Crop

Funded by the National Science Foundation.
Co-PIs are Justin Fay and Kevin Smith.

Moyers BT, Morrell PL, McKay JK. (preprint) Genetic cost of doemstication and improvement.
Preprint version

Kono JTY, Lei Li, Shih C-H, Hoffman PJ, Morrell PL, Fay JC. (preprint) Comparative genomics approaches accurately predict deleterious variants in plants.
Preprint version

Liu Q, Zhou Y, Morrell PL, Gaut BS. (2017) Deleterious variants in Asian rice and the potential cost of domestication. Molecular Biology and Evolution 34: 908-924.
Journal publicationPreprint version

Durvasula A, Hoffman PJ, Kent TV, Liu C, Kono TJY, Morrell PL, Ross-Ibarra J (2016). ANGSD-wrapper: utilities for analyzing next generation sequencing data. Molecular Ecology Resources 16: 1449-1454.
Journal publicationPreprint versionANGSD-wrapper Github

Kono TJY, Fu F, Mohammadi M, Hoffman PJ, Liu C, Stupar RM, Smith KP, Tiffin P, Fay JC, Morrell PL (2016). The role of deleterious substitutions in crop genomes. Molecular Biology and Evolution 33: 1669-1678.
Journal publicationPreprint versionBAD_Mutations Github

Gaut BS, Diez CM, Morrell PL (2015). Genomics and the contrasting dynamics of annual and perennial domestication. Trends in Genetics 31: 709-719.
Journal publication

Biotechnology Risks

Comparison of mutation rates in soybean following transformation, mutagenesis, tissue culture and conventional breeding

Funded by the Biotechnology Risk Assessment Research Grants Program (BRAG).
Awards page. [Link 1] [Link 2]
Co-Project Directors are Wayne Parrott, Scott Jackson, and Robert Stupar.

Kono JTY, Lei Li, Shih C-H, Hoffman PJ, Morrell PL, Fay JC. (preprint) Comparative genomics approaches accurately predict deleterious variants in plants.
Preprint version

Anderson JE, Michno JM, Kono TJY, Stec AO, Campbell BW, Curtin SJ, Stupar RM (2016). Genomic variation and DNA repair associated with soybean transgenesis: a comparison to cultivars and mutagenized plants. BMC Biotechnology 16: 41.
Journal publication